The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01584570

Enrollment

Registered

2012-04-25

Start date

2012-01-01

Completion date

2013-12-23

Last updated

2019-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, General

Keywords

dexmedetomidine, heart rate variability, QTc interval

Brief summary

The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.

Interventions

DRUG0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min

ECG monitoring for evaluation of QTc interval

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* patient who are regarded as ASA class I * age 20 to 60 * patient scheduled for Intubation for surgery

Exclusion criteria

* QTc interval \> 440 ms * arrythmia * Patient who is taking a medicine which effects QTc interval * HTN * DM * renal disease * hepatic disease * pregnant * illiterate

Design outcomes

Primary

Measure	Time frame	Description
Change of QTc interval	T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation)	T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026