Cardiovascular Disease
Conditions
Brief summary
Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva. Some nitrogen oxides are recycled with the help of oral bacteria to nitric oxide which is protective against vascular disorders. This study will test the hypothesis that females have different numbers and species of these nitrogen-oxide reducing bacteria.
Interventions
None listed
Sponsors
King's College London
Queen Mary University of London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form
Exclusion criteria
1. Healthy subjects unwilling to consent 2. History of hypertension, diabetes or hypertensive on BP measurement 3. Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result 4. History of any serious illnesses, including recent infections or trauma 5. Subjects taking systemic medication (other than the oral contraceptive pill) 6. Subjects with self-reported use of mouthwash or tongue scrapes 7. Subjects with recent or current antibiotic use (within 3 months) 8. Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacterial species identification | At baseline |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure | At baseline |
| Nitrogen oxide levels in biological fluids | At baseline |
| Oral nitrate reduction | At baseline |
| Bacterial count | At baseline |
Countries
United Kingdom
Outcome results
None listed