Postthoracoscopy Neuropathic Pain, Postthoracotomy Pain
Conditions
Brief summary
Neuropathic pain is due to a lesion or disease affecting the nervous system. Antidepressants (ADs) are recommended as the first line treatment. In a murine model, the investigators evidenced that antidepressants antiallodynic action is mediated through β2-adrenergic receptor stimulation and that β-mimetics display the same effect. These data support the idea that β-mimetics could offer a therapeutic alternative to ADs for neuropathic pain treatment. This study will aim at assessing the effects of terbutaline on neuropathic pain symptoms.
Interventions
DRUGTerbutaline sustained release 5 mg
Terbutaline 10mg oral per day (5 mg twice a day) during 28 days
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* adults from 18 to 75 years old * neuropathic painful condition following a thoracotomy or thoracoscopy for at least 3 months
Exclusion criteria
* cardiovascular risk * unstable diabetes mellitus * allergy for terbutaline * hypokaliemia without treatment * untreated hypothyroidism * HIV- or chemotherapy-induced neuropathy * cancer being treated by chemo- or radio-therapy * concomitant treatment with β-blockers, tricyclic ADs or morphine * concomitant pain more severe than neuropathic pain- pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in the average intensity of pain during the last 24 hours reported by the patient on a 11 points Numeric Scale | Day one, day 14 and day 28 of each 4 weeks period |
Countries
France
Outcome results
None listed