Atrial Fibrillation, Stroke, Acute
Conditions
Keywords
Anticoagulation, Recurrent stroke, Bleeding
Brief summary
The purpose of this study is to determine choice of anticoagulant therapy during acute and chronic stages of ischemic stroke/TIA and short- and long-term outcomes, including stroke recurrence and bleeding complications, in patients having nonvalvular atrial fibrillation.
Interventions
This is an observational, not intervention, study.
Sponsors
Ministry of Health, Labour and Welfare, Japan
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Consecutive acute ischemic stroke/TIA patients with NVAF
Exclusion criteria
1. Rheumatic mitral valve disease 2. A history of prosthetic valve replacement or mitral valve surgical repair 3. Active infective endocarditis 4. Patient, family member or legally responsible person does not have given informed consent 5. Inappropriate patient's conditions for study enrollment in the opinion of the investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ischemic events | 2 years | Recurrence of ischemic stroke/TIA, ACS, systemic embolism, aortic dissection, rupture of aortic aneurysm, peripheral artery disease (required hospitalization), VTE, revascularization (including CEA/CAS, PCI, etc) |
| major bleeding | 2 years | Major bleeding according to the ISTH definition, including fatal bleeding, intracranial hemorrhage, etc |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| modified Rankin Scale | 2 years | modified Rankin Scale |
| Modification of anticoagulant medication | 2 years | — |
Countries
Japan
Outcome results
None listed