Non Small Cell Lung Cancer
Conditions
Keywords
NSCLC, exercise intervention, quality of life
Brief summary
In the course of their disease patients with Non small cell lung cancer (NSCLC) often experience impaired psychological and physical functioning resulting in a reduced quality of life (QoL). The aim of the study is to explore the feasibility and the effects of an eight weeks combined muscle strength and endurance training on physical capacity and QoL.
Detailed description
In this open, prospective, single center study 40 patients (pts) with NSCLC undergoing adjuvant or palliative chemo-/ or radiotherapy are enrolled. Physical status is assessed by using the 6 Minute Walk Test (6MWT) for endurance and by using the Handheld Dynamometer (HHDM) for strength (flexion and extension of elbow, hip and knee). Psychological performance is measured by standardized questionnaires (MFI, FACT-L, PHQ - 9). Data are collected at baseline (T0) and after the 8 weeks sports intervention (T1). Pts are instructed to train at least 5 times/ week in the inpatient setting. After discharge pts are instructed to train in a home-based setting at least 3 times/week for a period of 8 weeks. Feasibility is defined as an adherence of two trainings per week during at least 6 weeks (out of 8 weeks of the intervention).
Interventions
OTHERExercise intervention
Pts were instructed to train at least 5 times/ week in the inpatient setting. After discharge pts were instructed to train in a home-based setting at least 3 times/week for a period of 8 weeks.
Sponsors
Heidelberg University
German Cancer Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male and female patients * histological confirmed diagnosis of Non small cell lung cancer (NSCLC) * current treatment: chemo-and/or radiotherapy * age \> 18y * Body Mass Index (BMI) \> 18 * written informed consent
Exclusion criteria
* acute infection * immobility \> 2 days * severe neurological impairment * severe cardiac impairment * severe pulmonal impairment * severe renal impairment * acute bleedings * alcohol-/drug-abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| - number of patients who are adherent to the exercise intervention | 8 months | Adherence is defined as: completion of at least two training sessions per week during minimum six weeks out of eight weeks of the intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| - effects of the exercise intervention on psychological symptoms (e.g. quality of life) | 8 months | Quality of life will be measured by the standardized and validated questionnaire FACT-L; |
| - effects of the exercise intervention on physical symptoms (muscle strength and endurance) | 8 months | Muscle strength will be measured by hand held dynamometry and endurance by 6 Minute Walk Test |
Countries
Germany
Outcome results
None listed