Renal Acute MI Study

Renal Structural, Functional and Cytokine Responses to Acute Myocardial Injury in Man

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01580566

Enrollment

Registered

2012-04-19

Start date

2012-03-31

Completion date

2018-09-30

Last updated

2019-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Function, Myocardial Infarction

Keywords

Myocardial Infarction (MI), Kidney function, bio-markers

Brief summary

The purpose of this study is to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). To determine if the renal response to a myocardial infarction is a predictor of the patients future health.

Detailed description

Chronic heart and kidney disease are increasingly common in Western society. Both conditions are associated with frequent hospitalisation and increased mortality. Furthermore, there are mechanistic reasons why one condition may beget the other; the so-called cardiorenal syndrome. The investigators therefore wish to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). The investigators also wish to determine if the renal response to a myocardial infarction is a predictor of the patients future health. To do this the investigators will measure markers of kidney function at the time of the heart attach, at discharge, 1 month, 6 months and 12 months and correlate this with the patients clinical condition.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Age \> 18 years Have provided written informed consent Group 1: * Non-Q wave MI patients * normal cardiac and renal function * No use of contrast * eGFR \> 60ml/min Group 2: * Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI * normal cardiac and renal function * eGFR \> 60ml/min Group 3: * Acute STEMI Full thickness infarct (STEMI) * eGFR ≥ 60ml/min Group 4: * Acute STEMI Full thickness infarct (STEMI) * eGFR \< 60ml/min

Exclusion criteria

* Unable or unwilling to comply with the study protocol * Underlying medical condition which, in the opinion of the investigator, will effect the safely or efficacy of the study

Design outcomes

Primary

Measure	Time frame
changes in renal function and structure	Baseline, discharge, 1 month, 6 months and 12 months

Secondary

Measure	Time frame
renal response to myocardial infarction	baseline, discharge, 1 month, 6 months and 12 months

Countries

Australia

Outcome results