Compare Blood Age for Transfusion
Conditions
Keywords
Blood, Storage, Age, Transfusion, Lactic acidosis
Brief summary
In resolving lactic acidosis among children with severe malarial anemia, there is no difference between those transfused with blood of longer storage compared to shorter storage age
Detailed description
Objective of the study is to evaluate the effect of blood storage age on resolution of lactic acidosis in children with severe malarial anemia. Methods: Children aged 6 - 59 months admitted to ACU with Severe Malarial Anemia (Hb \<5g/dl) and Lactic Acidosis (blood lactate \>5 mmol /l), will be randomly assigned to receive either blood of shorter storage age (\<10 days) or longer storage age (21 -35 days) by gravity infusion as is the routine practice. 37 patients will be enrolled in each study arm. Physiological measurements namely blood lactate, oxygen saturation, Hemoglobin, Blood pressure, respiratory rate and pulse rate will be taken at baseline, during and after transfusion. The two groups will be compared. The primary outcome variable will be the proportion of children whose lactic acidosis resolves after 4 hrs of transfusion. 24hr mortality will be our secondary outcome.
Interventions
BIOLOGICALBlood transfusion
The short storage arm; children were transfused with packed red cells of storage age 1-10 days; while for the Long storage arm; were transfused with packed red cells of 21- 35 days in storage.
Sponsors
Makerere University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
6 Months to 59 Months
Healthy volunteers
No
Inclusion criteria
Children aged 6 - 59 months admitted at Acute care Unit - Mulago hospital with; 1. A positive B/S for malaria 2. Severe anemia ( Hb ≤ 5 g/dl) and 3. Lactic Acidosis (Blood lactate ≥ 5 mmol/l) 4. Written informed consent from the caretaker.
Exclusion criteria
1. Children undergoing transfusion with blood products other than packed cells. 2. Children with known or concurrent cardiac disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of blood storage age on the resolution of lactic acidosis in children with severe malarial anemia at Mulago hospital | 4hrs | The proportion of transfused patients who resolve lactic acidosis within 4 hours of transfusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of blood storage age on the resolution of lactic acidosis in children with severe malarial anemia at Mulago hospital | 24 HRS | proportion of children who die within 24 hrs. |
Countries
Uganda
Outcome results
None listed