Adaptive Family Treatment for Adolescent Anorexia Nervosa

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01579682

Enrollment

Registered

2012-04-18

Start date

2011-09-30

Completion date

2015-12-31

Last updated

2016-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Keywords

Eating Disorder, Anorexia Nervosa, Eating Disorder Not Otherwise Specified, Maudsley, Family-Based Therapy, FBT, Family Therapy

Brief summary

Anorexia Nervosa (AN) has the highest mortality rate compared to any other psychiatric disorder. The most promising treatment for adolescents with AN is family-based treatment (FBT). However, only 50% of patients receiving FBT fully remit at 12-month follow-up. Consequently, providing an alternative therapy early in the treatment course for those not responding to FBT may enhance overall outcome. This study aims to develop a new treatment - Intensive Family-Focused Treatment (IFT) - to improve outcomes in those adolescents, aged 12-18 years, who do not show an early response to FBT.

Interventions

BEHAVIORALFamily-Based Therapy (FBT)

12 sessions of FBT over the course of 6 months.

BEHAVIORALFamily-Based Therapy with Intensive Family-Focused treatment

FBT for 4 weeks then Intensive Family-Focused treatment (IFT) should the participant not make adequate weight progress within the time frame.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

12 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Meets DSM-IV criteria for anorexia nervosa * Lives with at least one English-speaking parent who is willing to participate * Medically Stable * Adequate transportation to clinic * Proficient at speaking, reading, and writing English

Exclusion criteria

* Previous FBT for AN * Medical condition that may affect eating or weight

Design outcomes

Primary

Measure	Time frame	Description
Full remission from AN (%MBW>95)	End of Treatment (6 months)	Weight restoration to at least 95% of Median body weight (calculated by height, weight, gender, and age)

Secondary

Measure	Time frame	Description
Changes in subscale scores of the EDE	End of Treatment (6 months)	Eating Disorder Examination subscale measures (weight concern, shape concern, dietary restraint) within 1 standard deviation of normative scores.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026