Pain Control
Conditions
Brief summary
The investigators examined the effect of dexmedetomidine in the management of pain after uterine artery embolization.
Detailed description
Leiomyoma are the most common female reproductive tract tumors. Uterine artery embolization(UAE) is a minimally invasive treatment alternative to hysterectomy and myomectomy. However, post-procedural pain control after UAE remains a major problem. Therefore, the aim of study is to evaluate the efficacy of dexmedetomidine in pain control after UAE.
Interventions
DRUGDexmedetomidine
Dexmedetomidine(Dexmedetomidine 2 mL and normal saline 98 mL mixed -\> 2㎍/mL) : the infusion of 0.2㎍/kg/hr is started at 30 minutes before the procedure and the infusion dose is raised to 0.4㎍/kg/hr after completion of procedure
DRUGNormal saline 0.9%
Normal saline 100mL(guess as 2㎍/mL):the infusion of 0.2㎍/kg/hr is started at 30 minutes before the procedure and the infusion dose is raised to 0.4㎍/kg/hr after completion of procedure
Sponsors
Severance Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥ 20, * ASA class I and II
Exclusion criteria
* bradycardia (\< 45 bpm) * heart block * liver failure * renal failure * uncontrolled hypertension * body mass index ≥ 30 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fentanyl consumption by patient-controlled analgesia | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Side effects | 24 hours |
Countries
South Korea
Outcome results
None listed