Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT)

Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01577446

Acronym

NARROW-CRT

Enrollment

120

Registered

2012-04-13

Start date

2008-01-31

Completion date

Unknown

Last updated

2016-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure, Systolic

Keywords

CRT, heart failure, narrow QRS, dyssynchrony

Brief summary

Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT). This study was designed to test the hypothesis that patients with heart failure of ischemic origin, current indications for defibrillator implantation and QRS \<120ms may benefit from CRT in the presence of marked mechanical dyssynchrony.

Interventions

PROCEDUREcardiac resynchronization therapy

Implantation of a CRT defibrillator with a standard right atrial, right ventricular defibrillator and left ventricular leads

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* NHYA class II-III heart failure * ischemic cardiomyopathy * ejection fraction of 35% or less * QRS interval of 120ms or less * evidence of mechanical dyssynchrony as measured on echocardiography

Exclusion criteria

* conventional indication for cardiac pacing * persistent atrial fibrillation * life expectancy lower than 1 year

Design outcomes

Primary

Measure	Time frame	Description
heart failure clinical composite score	12 months	Patients are classified according to a score, which assigns subjects to one of three response groups - improved, worsened, or unchanged. Patients are judged to be worsened if they died or were hospitalized because of worsening heart failure (at any time during the 12 months), or demonstrated worsening in NYHA functional class at their 12-month visit. Patients are judged to be improved if they had not worsened and had demonstrated improvement in NYHA functional class at 12 months. Patients who are not worsened or improved are classified as unchanged.

Secondary

Measure	Time frame	Description
time to the first heart failure hospitalization or death	up to 30 months	Kaplan-Meier analysis is used to analyze time to death or first heart failure hospitalization

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026