Prehypertension, Stage-1 Hypertension
Conditions
Brief summary
Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.
Interventions
DIETARY_SUPPLEMENTNon-fat dairy
Add 4 daily servings per day of non-fat dairy (yogurt, milk, cheese) for a period of 4 weeks
DIETARY_SUPPLEMENTAdd 4 servings fruit
Add 4 daily servings of fruit (fruit cup, apple sauce, orange juice) and remove all dairy for a period for 4 weeks
Sponsors
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Prehypertension or stage-1 hypertension
Exclusion criteria
* Consume \> 3 servings of dairy or fruit per day * Strenuous physical activity \> 3 time per week * Lactose intolerance, pregnancy, lactation, and/or alcohol abuse * Taking cardiovascular-acting drugs * Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seated blood pressure | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure | 4 weeks |
| Carotid arterial compliance | 4 weeks |
| Arterial stiffness | 4 weeks |
| Flow mediated dilation | 4 weeks |
Countries
United States
Outcome results
None listed