Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide

Zinc Absorption From Zinc Supplements Comparing Zinc Citrate to Zinc Gluconate and Zinc Oxide in Young Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01576627

Enrollment

Registered

2012-04-12

Start date

2012-03-31

Completion date

2012-11-30

Last updated

2013-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.

Interventions

DIETARY_SUPPLEMENTzinc citrate

10 mg of zinc as either zinc citrate

DIETARY_SUPPLEMENTZinc Gluconate

10 mg of zinc as either zinc gluconate

DIETARY_SUPPLEMENTZinc oxide

10 mg of zinc as either zinc oxide

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Male or female of 18 to 45 years old * Body Mass Index in the range of 19 to 25 * No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion criteria

* Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement) * Long-term medication during the whole study (except for contraceptives) * Vegans * Pregnancy * Lactation * Intention to become pregnant during the course of the study * Lack of safe contraception * Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration * Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Design outcomes

Primary

Measure	Time frame	Description
Fractional absorption of zinc	61 days	Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 22, 2026