Total Hip Arthroplasty, Total Knee Arthroplasty
Conditions
Keywords
Anaesthesia, Infiltration, Blood transfusion, Autologous, Arthroplasty, Replacement, Ropivacaine
Brief summary
Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions. Especially comorbidity like cardiovascular diseases and conditions with increased risk of bleeding or previous thrombo-embolic events are major challenges. To facilitate safe use of ropivacaine as an analgesic, information on the concentrations levels after autologous blood transfusion following local infiltration analgesia is very crucial. However, very limited data are available. To verify the safety of autologous blood transfusion, ropivacaine concentrations were studied in 52 patients undergoing either total knee arthroplasty or total hip arthroplasty.
Interventions
DRUGAutologous blood transfusion with ropivacaine
Local infiltration analgesia with ropivacaine 3 mg/kg, max 200 mg
Sponsors
Northern Orthopaedic Division, Denmark
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis for hip arthroplasty * Clinical diagnosis for knee arthroplasty
Exclusion criteria
* Patients \< 18 years * Lack of informed consent * Inability to read/understand Danish * Bilateral diagnosis * Cancer diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentrations of ropivacaine in serum | 6 hours | Concentrations of ropivacaine in serum before and after autologous blood transfusion will be analyzed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of ECG and pulse rate | 6 hours | ECG, pulse rate and blood pressure will be analyzed in proportion to concentrations of serum before and after autologous blood transfusion |
Countries
Denmark
Outcome results
None listed