Chronic Idiopathic Hyperventilation, Dysfunctional Breathing, Hyperventilation, Respiratory Alkalosis
Conditions
Keywords
Hyperventilation, Chronic Idiopathic Hyperventilation, Dysfunctional Breathing, Respiratory Alkalosis, Respiratory Acidosis
Brief summary
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively. The investigators hypothesised that by periodically inducing normocapnia over several weeks, it would be possible to raise the normal resting level/set point of CO2 and achieve a reduction of symptoms. Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing mask. The mask was used to induce normocapnia in these chronically hypocapnic patients. Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline and once each week at least three hours after mask use, as well as spirometric values, breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire (NQ),.
Interventions
DEVICEPartial Rebreathing Mask
Inducing normal CO2 for two hours a day for four weeks
Sponsors
Rehaler
University of Aarhus
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Chronic idiopathic hyperventilation, i.e.: * PCO2 level below 4.7 kPa AND * SBE value more negative than -1.0
Exclusion criteria
* Oxygen saturation of 95% or lower at rest
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood gas and acid/base status | Once every week in the treatment period of four weeks | pH, PCO2, PO2, Standard Base Excess |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hyperventilation symptoms | once a week | Nijmegen Questionnaire |
| Breath Hold Tolerance | once a week | — |
| Spirometric values | once a week | FEV1, FVC |
Countries
Denmark
Outcome results
None listed