Meniere Disease, Vertigo
Conditions
Keywords
stellate ganglion block., Meniere's disease., electrocochleography., vertigo., hearing impairment.
Brief summary
Stellate ganglion block (SGB) has been the alternative treatment of Meniere's disease for years. However, objective evidence of the effect of SGB was still lack. The investigators conducted a randomized controlled study to examine the immediate effects of SGB in SP/AP of electrocochleography (ECoG).
Detailed description
Ten patients were randomly assigned to receive stellate ganglion block. These ten patients made up the experimental group. Another ten patients in the control group were assigned to receiving one dosage of oral medications: 0.25mg of erispan@ (fludiazine) , 25mg cephadol@ (diphenidol), and 200mg kentons@ (tocopherol nicotinate).
Interventions
PROCEDUREstellate ganglion block
stellate ganglion block
DRUG0.25mg, fludiazine
0.25mg of erispan@ (fludiazine), p.o. one dose only.
DRUG25mg cephadol@ (diphenidol)
25mg cephadol@ (diphenidol) p.o. one dose only.
DRUG200mg kentons@ (tocopherol nicotinate).
200mg kentons@ (tocopherol nicotinate) p.o. one dose only.
Sponsors
Chi Mei Medical Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients diagnosed with unilateral Meniere's disease, according to the criteria of the American Academy of Otolaryngology-Head and Neck Surgery, AAO-HNS (1995)
Exclusion criteria
* patients with coagulopathy, * arrhythmia, * myocardial ischemia, * glaucoma, * pregnant, * chronic otitis media or externa, and * past history of middle or inner ear surgery were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SP/AP of Electrocochleography | ECoG was reorded 2 hours after SGB | SP/AP of ECoG was recorded 2 hours after SGB. to be compared with the SP/AP of ECoG recorded before treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SP/AP recorded at 4 hours after SGB | 4 hours after SGB | SP/AP recorded at 4 hours after SGB was compared with that of pretreatment with SGB |
| SP/AP recorded at 6 hours after SGB | 6 hours after SGB | SP/AP recorded at 4 hours after SGB was compared with the SP/AP recorded before SGB |
| scores of verbal scale for vertigo recorded at 6 hours after SGB | 6 hours after SGB | scores of verbal scale for vertigo recorded at 6 hours after SGB was compared to the scores recorded before SGB |
Countries
Taiwan
Outcome results
None listed