Microvascular Function Assessment in Healthy Subjects

Amélioration Des Techniques d'étude de la Micro-cirulation cutanée Chez Des Sujets Sains

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01572961

Acronym

MICROTEC

Enrollment

Registered

2012-04-06

Start date

2010-11-30

Completion date

2013-05-31

Last updated

2016-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physiology of Microvascular Skin

Keywords

Laser Doppler flowmetry, skin, microcirculation

Brief summary

Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2) whether this amplification relies on prostaglandin-sensitive mechanisms. A double-blind randomized placebo-controlled crossover trial is conducted in Angers, France.

Interventions

DRUGacetylsalicilic acids (Aspirin)

single oral dose of 1g.

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Age \> or equal to 18 years old * Healthy subjects

Exclusion criteria

* Aspirin allergy

Design outcomes

Primary

Measure	Time frame
The increase of Laser Doppler Blood Flow after the second current stimulation	1 hour

Secondary

Measure	Time frame
The increase of Laser Doppler Blood Flow after the second current stimulation after aspirin administration	1 hour

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026