Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01572467

Enrollment

Registered

2012-04-06

Start date

2012-04-30

Completion date

Unknown

Last updated

2016-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Germ Cell Tumor, Leydig Cell Tumor, Ovarian Cancer

Keywords

Leydig cell tumor, ovarian stromal cancer, childhood malignant testicular germ cell tumor, childhood malignant ovarian germ cell tumor

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.

Detailed description

OBJECTIVES: * To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors. OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.

Interventions

GENETICRNA analysis

GENETICgene expression analysis

GENETICmutation analysis

GENETICreverse transcriptase-polymerase chain reaction

OTHERlaboratory biomarker analysis

OTHERmedical chart review

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 120 Years

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and Massachusetts General Hospital * Tissue samples from patients diagnosed with: * Ovarian * Sertoli-Leydig cell tumor * Juvenile granulosa cell tumor * Adult granulosa cell tumor * Gynandroblastoma * Sex cord stromal tumor with annular tubules * Sex cord stromal tumor, undifferentiated * Sertoli tumor * Leydig tumor * Testicular: * Granulosa cell tumor * Sertoli tumor * Leydig tumor * Sertoli-Leydig * Undifferentiated stromal tumor PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026