Postprandial Insulin Secretion, Oxidative Stress and Gastrointestinal Peptides in Patients With Type 2 Diabetes Versus Healthy Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01572402

Enrollment

100

Registered

2012-04-06

Start date

2012-01-31

Completion date

2012-05-31

Last updated

2012-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postprandial Oxidative Stress, Type 2 Diabetes

Keywords

Diet, Gastrointestinal peptides, Insulin secretion, Oxidative stress, Plasma lipids, Postprandial, Type 2 diabetes

Brief summary

Insulin secretion, plasma lipids, oxidative stress markers and gastrointestinal peptides will be measured in patients with type 2 diabetes versus healthy subjects in a fasting status and in response to standard meals (at times 0', 30', 60', 120' and 180').

Interventions

OTHERBagueutte Cheese Gourmet (Crocodille)

180g, energy 452.8 Kcal/1895.7 kJ, composition: carbohydrates 49,2 g (44,55%), proteins 18,5 g (16,74%), lipids 18,8 g (38,7%), of which saturated 6,8 g, monounsaturated 6,0 g, polyunsaturated 5,0 g.

OTHERCous-cous sandwich

235 g, energy 455,88 Kcal /1907,4 kJ, composition: carbohydrates 59,54 g (52,24%), proteins 12,47 g (10,57% %), lipids 18,85 g (37,31%), of which saturated 6,2 g, monounsaturated 11,49 g, polyunsaturated 28,26 g

OTHERMcCountry sandwich (McDonald's)

150g, 455 kcal/1903,72 kJ, composition: carbohydrates 31 g (27,25%), proteins 24 g (21,1%), lipids 26 g (51,43%), of which saturated 10 g (38,45%)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* 40 individuals with type 2 diabetes treated by diet only or oral hypogylycemic agents, * diabetes duration at least 1 year, * both men and women, * age 30-65 years, * BMI 27-50 kg/m². The subjects will be explained aims, methods and risks of the study and they will sign informed consent

Exclusion criteria

* gravidity, * lactation, * drug abuse, * insulin therapy

Design outcomes

Primary

Measure	Time frame
Postprandial oxidative stress	up to 2 months
Postprandial plasma concentrations of gastrointestinal peptides	up to 2 months

Secondary

Measure	Time frame
Postprandial insulin secretion - relationship to oxidative stress and gastrointestinal peptides	up to 2 months
Postprandial plasma lipids	up to 2 months

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026