Idiopathic Thrombocytopenic Purpura
Conditions
Keywords
rebalanced hemostasis, idiopathic thrombocytopenic purpura, coagulation status
Brief summary
The investigators are trying to investigate the coagulation status of idiopathic (immune) thrombocytopenic purpura patients by measuring the platelet count, coagulation battery, von Willebrand factor level, thromboelastography.
Detailed description
In patients with chronic coagulation disorder, laboratory model and clinical data have shown evidence for a rebalanced hemostasis. Previous study showed that the platelet count may not predict the risk of bleeding since the platelet count is not an indicator of platelet function. Thromboelastography may be the choice of investigation when platelet function is in question especially in patients with idiopathic (immune) thrombocytopenic purpura (ITP). Previous study have shown that maximum clot formation is the most important thromboelastography parameter in predicting bleeding in ITP patients that makes thromboelastography superior to other hemostatic tests. The investigators are trying to evaluate the rebalanced hemostasis in patients with ITP by comparing the value of platelet count, von Willebrand factor antigen level, and thromboelastography parameters.
Interventions
None listed
Sponsors
Samsung Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Those who visits the outpatients clinic of Samsung Medical Center with a diagnosis of idiopathic (immune) thrombocytopenic purpura (ITP)between March, 2012 and February, 2013. * Those with age between 20 and 70 yrs old
Exclusion criteria
* Those with other causes of thrombocytopenia other than ITP
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum clot formation | within 3 hour of blood sampling | thromboelastography parameters performed within 3 hours of blood sampling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Coagulation battery results | within 1 hour after blood sampling | prothrombin time (%, second, INR) activated partial thromboplastin time (sec) fibrinogen level (mg/dL) |
| von Willebrand factor antigen | within 3 hours of blood sample | von Willebrand factor antigen level |
| clotting time | within 3 hours of blood sampling | clotting time of Thromboelastography |
| alpha angle | within 3 hours of blood sample | alpha angle of thromboelastography parameter |
| platelet count | within 1 hours of blood sampling | platelet count |
| LY 60 | within 3 hours of blood sampling | maximum amplitude at 60 minutes of thromboelastography parameter |
| CLI | within 3 hours of blood sampling | clot lysis index of thromboelastography parameter |
| Maximum lysis | within 3 hours of blood sampling | Maximum lysis of thromboelastography parameter |
| A10, A15, A20, A25 | within 3 hours of blood sampling | amplitude 10, 15, 20, 25 minutes (mm) of thromboelastography parameter |
Countries
South Korea
Outcome results
None listed