Subfertility
Conditions
Brief summary
What is the best medication for hormonal stimulation in cycles with high intra-uterine insemination: tablets of Clomifen (5 days) followed by tablets of Ethinyl Estradiol (5 days) or daily injections with Human Menopausal Gonadotropin (Menopur)?
Interventions
DRUGClomifen, Ethinyl Estradiol
starting on day 2 or 3 of the cycle: 1 tablet of Clomifen each day, for 5 days in a row. Dose 50mg or in subsequent cycles, 25 mg or 100 mg or 150 mg. After the 5 days of Clomifen, one tablet of Ethinyl Estradiol 50 mg per day, for 5 days in a row or until beta hCG is injected
DRUGMenotropins
Starting on day 2 or 3 of the cycle, a daily subcutaneous injection of 37.5 IU or 75.0 IU
Sponsors
University Hospital, Gasthuisberg
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* women younger than 42 years old * infertility of at least one year * normal tubal, pelvic and uterine anatomy * semen with total motility count of at least 5 million (at least one sample)
Exclusion criteria
* premature ovarian failure * medical history of tubal or ovarian surgery * tubal or pelvic adhesions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate | on average 30 days if not pregnant and 12 weeks if pregnant |
Countries
Belgium
Outcome results
None listed