Genetic Influence on Statin Pharmacodynamics

An Observational Study Investigating Genetic Influences on Clinical Outcomes and Change in Carotid Intimal Thickness in Adults Taking Atorvastatin, Simvastatin, or Lovastatin

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01569854

Enrollment

Registered

2012-04-03

Start date

2012-03-31

Completion date

2022-03-31

Last updated

2016-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslipidemia, Hypercholesterolemia, Hyperlipidemia

Brief summary

The study intends to investigate whether genetics influence how individuals respond to statins (clinical outcomes and changes in carotid intimal media thickness)

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* recently (within past 3 months) started taking atorvastatin, lovastatin, or simvastatin

Exclusion criteria

* concomitant uses of medications, supplements, or OTCs known to interfere with statin metabolism

Design outcomes

Primary

Measure	Time frame	Description
carotid intimal media thickness (CIMT)	2 years	CIMT measurements will be performed at baseline (within 3 months of starting statin) and at 6, 12, 18, and 24 months. Change in CIMT is considered a surogate measure of atherosclerotic progression.

Countries

United States

Outcome results