Low Volume PEG With Low Residue Test Meals Versus High Volume Split-dose PEG Bowel Preparation

Efficacy and Tolerability of Morning (AM) Only Low Volume (2L) PEG With Low Residue Test Meals Versus High Volume (4L) Split-dose (PM/AM) PEG Bowel Preparation With Standard Meals: A Prospective Randomized, Investigator Blinded Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01568814

Acronym

LOWPEG

Enrollment

188

Registered

2012-04-02

Start date

2012-01-31

Completion date

2012-03-31

Last updated

2012-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Preparation, Colonoscopy

Keywords

colonoscopy, bowel preparation, polyethylene glycol, low residue meal

Brief summary

Morning only low volume PEG with low reside meals may enhance patient tolerability and have similar bowel cleansing efficacy compared to standard method using high volume split-dose PEG with standard diet.

Detailed description

We aimed to evaluate the efficacy and tolerability of bowel preparation protocols with low volume PEG and low residue meals PEG compared to conventional high volume (4L) split-dose and standard diet. Entry criteria: Entry criteria: Adult outpatients and inpatients (18-85 years of age) who undergo colonoscopy for screening, cancer surveillance or with gastrointestinal symptoms, other symptoms Primary Outcome: Quality of bowel preparation (Ottawa scale) Secondary Outcome: Tolerability (preparation completion, side effect), acceptance, willingness

Interventions

DRUGLow volume PEG

low volume polyethylene glycol 2 liter one time

DRUGhigh volume PEG

high volume polyethylene glycol 4 lilter split-dosing 2L/2L two times

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Adult outpatients and inpatients (18-85 years of age) who undergo colonoscopy for screening, cancer surveillance or with gastrointestinal symptoms, other symptoms

Exclusion criteria

* Age under 18 years * Pregnancy * Breast feeding * Prior history of surgical large bowel resection * Severe medical condition such as severe cardiac * Hepatic, renal failure (creatinine ≥ 3.0mg/dL (normal 0.8-1.4)) * Drug addiction or major psychiatric illness * Suspected bowel obstruction or ileus * Allergy to PEG * Refusal of consent to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Quality of bowel preparation	2 months	Quality of bowel preparation is assessed using Ottawa bowel preparation scale.

Secondary

Measure	Time frame	Description
Tolerability	2 months	Tolerability of bowel preparation regimen is assessed by patient questionnaire.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026