Barrett's Esophagus
Conditions
Keywords
Barrett's esophagus, high grade dysplasia, ablation, radiofrequency ablation, esophageal cancer
Brief summary
The purpose of this study is to determine biomarkers which can predict response to ablation therapy in patients with Barretts esophagus.
Detailed description
This Project is designed to identify biologically-based and clinically-useful biomarkers of tissue at risk for neoplastic progression as well as of response to ablation therapy. These results will result in improved risk stratification in BE and better targeting of resources for patients who are candidates for ablative therapy, while simultaneously providing key information regarding the origins of Barrett's esophagus.
Interventions
GENETICresponse to therapy
evaluate specific markers for response to therapy at specific intervals pre and post therapy
Sponsors
National Cancer Institute (NCI)
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Barrett's esophagus with high grade dysplasia or intramucosal (early) adenocarcinoma. * BE length ≥ 2 cm and ≤ 8 cm. * Able to return every 3 months for one year after ablation
Exclusion criteria
* Patients who are unable to be compliant with follow-up endoscopies * patients who cannot tolerate Proton Pump inhibitors * pre-existing esophageal strictures * pregnant or nursing women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response to therapy | one year post ablation | evaulation will be made at 3 month intervals for one year post ablation |
Countries
United States
Outcome results
None listed