Circulating SIRT6 Expression, Effect on Aging Quality

Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01567176

Acronym

Sirt6

Enrollment

Registered

2012-03-30

Start date

2012-03-31

Completion date

2012-09-30

Last updated

2019-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Keywords

Sirtuins, Aging, Metabolic disease

Brief summary

This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Interventions

BIOLOGICALBlood sample

It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Volunteers from the SUVIMAX 2 aging cohort * Men and women * Older than 60 * Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study * Covered by Health Insurance System

Exclusion criteria

* Subject not in compliance with the recommendation of French National Law

Design outcomes

Primary

Measure	Time frame	Description
Sirt6 expression in circulating leukocytes based on the aging quality	participants will be followed for the duration of the visit, an expected average of 1 day	analysis by quantitative RT-PCR method

Secondary

Measure	Time frame	Description
hand and forearm muscular strength measurement	participants will be followed for the duration of the visit, an expected average of 1 day	Hand Grip strength test
Physical examination and anthropometric measurement	participants will be followed for the duration of the visit, an expected average of 1 day	Measurement of the weight, height, waist, hips, blood pressure, pulse.
Cognitive assessment	participants will be followed for the duration of the visit, an expected average of 1 day	MMSE (Mini Mental State Examination), Five-word test, clock drawing
Physical Activity questionnaire	participants will be followed for the duration of the visit, an expected average of 1 day	MAQ (Modifiable Activity Questionnaire)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026