Effect of Cefazolin and Normal Saline Irrigation on Surgical Site Infections (SSIs)

Comparison of the Effect of Cefazolin and Normal Saline Irrigation With no Irrigation on the Incidence of Surgical Site Infections

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01566734

Enrollment

200

Registered

2012-03-29

Start date

2010-12-31

Completion date

2012-02-29

Last updated

2012-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical Site Infections

Keywords

Surgical Wound Infection, cefazolin, Cesarean Section

Brief summary

This study conducted to assess the effects of normal saline or cefazolin irrigation on the incidence of SSIs. Hypothesis: Normal saline or cefazolin irrigation decreases the incidence of SSIs.

Detailed description

All pregnant women who underwent cesarean after 6 hours passed their rupture of membrane and attended to Shariati Hospital of Bandarabbass were eligible for our study.

Interventions

OTHERCefazolin irrigation

after the surgery and before closing up the patients, 2 grams of cefazolin in 5 cc of distilled water was used to irrigate the patients

OTHERNormal Saline Irrigation

after the surgery and before closing up the patients, 150 cc of normal saline was used to irrigate the patients and in the last group

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* pregnant women * 6 hours passed their rupture of membrane * needed to undergo cesarean

Exclusion criteria

* allergy to penicillin * allergy to cefazolin * history of immunosuppressive drug use * gestational diabetes mellitus * preeclampsia

Design outcomes

Primary

Measure	Time frame
SSI	one week after discharge

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026