Sleep and Cerebral Responses to High Altitude

Intolerance Mechanisms and Exercise Performance Limitation During a High Altitude Stay: Investigation of Sleep and Cerebral Responses

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01565603

Acronym

VALLOT 2011

Enrollment

Registered

2012-03-28

Start date

2011-07-31

Completion date

2012-10-31

Last updated

2012-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Mountain Sickness, High Altitude Cerebral Edema, High Altitude Pulmonary Edema

Keywords

Hypoxia, Exercise, Sleep, Brain, Neuromuscular function, Heart

Brief summary

Mechanisms underlying high-altitude intolerance as well as exercise performance limitation in hypoxia still remain to be fully understood. Recent data suggest that sleep disturbances on one hand and cerebral perturbations on teh other hand may be key mechanisms. The investigators evaluated 12 healthy subjects at sea level and at 4400 m of altitude for 7 days in order to better describe sleep and cerebral responses. The investigators hypothesized that sleep and cerebral disturbances play a critical role for the developement of acute mountain sickness and for exercise performance limitation during acute high-altitude exposure.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 to 50 yrs old * Male

Exclusion criteria

* Respiratory, cardiac, metabolic or neuromuscular diseases * History of severe acute mountain sickness

Outcome results