Knee Osteoarthritis
Conditions
Keywords
Osteoarthritis, Pain, Quality of life
Brief summary
Biofreeze® is a topical ointment that has menthol and alcamphor. Its analgesic effect lies in the stimulation of A and C fibers by cold and nociceptive stimulation, respectively, which is produced by menthol, apparently through the newly discovered receptor TRPM8 (Transient Receptor Potential melastatin-8) The aim of this study is to investigate if BIOFREEZE ® treatment (Performance Health Inc., Export, PA) improves symptoms associated with moderate knee osteoarthritis, which would decrease the immobility and isolation in older adults.
Interventions
DRUGBiofreeze
Use of Biofreeze ointment
OTHERPlacebo
Use of placebo ointment
Sponsors
University of Chile
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Moderate osteoarthritis of the knee * Age 60 to 80 years * Ambulatory
Exclusion criteria
* Other conditions that affect mobility * Severe chronic diseases such as cardiac or renal failure * Cancer * Presence of gout * Cognitive impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| WOMAC score | 60 days | WOMAC score corresponds to Western Ontario and McMaster Universities Index of Osteoarthritis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life measured using SF 36 | 60 days | SF 36 correponds to a health related quality of life score |
Countries
Chile
Outcome results
None listed