Cough Determinants in Mechanically Ventilated Patients

Cough Determinants in Mechanically Ventilated Patients: a Physiological Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01564745

Acronym

Extu-Cough

Enrollment

180

Registered

2012-03-28

Start date

2012-03-31

Completion date

2015-12-31

Last updated

2019-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation

Brief summary

In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough. In order to determine some determinants of cough, the investigators propose to evaluate systematically different physiological parameters before and after extubation.

Detailed description

In order to evaluate, and identify the cough determinants, the investigators propose a physiological evaluation for each patients who were intubated and mechanically ventilated during at least 72 hours. Indeed inefficacy of cough after extubation is one of the main reason of extubation failure. However there is no any mean to evaluate it simply now.

Interventions

OTHERFunctional respiratory evaluation

Each enrolled patients has a pulmonary function test before and after extubation, and repeatedly at D1, D3, D5 (if they are always hospitalized)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients mechanically ventilated since 72h * Age \> 18 years * Hospitalized in Intensive care Unit * In weaning phase - with the classically criteria to be extubated * Patients who passed the weaning test (T tube test or other)

Exclusion criteria

* Hemodynamic instability * Absence of consent * No cooperation of the patient * Hemodynamic instability * pH \< 7,30 * Severe hypoxemia

Design outcomes

Primary

Measure	Time frame	Description
Interest of systematically cough evaluation before extubation	2 days after extubation	All the patients enrolled have a physiological evaluation before and after extubation. After extubation the evaluation will be done respectively at D0, D1, D3 and D5. The first endpoint is the success of extubation which is evaluated à D2.

Secondary

Measure	Time frame
Correlation between success of extubation and respiratory parameters	2 days after extubation

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026