Dengue
Conditions
Keywords
dengue
Brief summary
This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.
Interventions
commercial permethrin insecticide impregnation of clothing before transmission season
OTHERwashing
normal washing of school uniforms, without permethrin insecticide impregnation
Sponsors
European Union
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
7 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
* pupils in participating schools
Exclusion criteria
* skin sensitivity, exema
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children | up to 2 years | Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups. |
Secondary
| Measure | Time frame |
|---|---|
| comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms | up to 2 years |
Countries
Thailand
Outcome results
None listed