Change in Brain Metabolism and Cognitive Function by Aripiprazole

The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01562808

Enrollment

Registered

2012-03-26

Start date

2009-01-31

Completion date

2012-01-31

Last updated

2012-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antipsychotics, Brain Metabolism, Cognition, Dopamine Receptor Occupancy

Brief summary

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task. The investigators explored the relationship between changes in brain metabolism and working memory performance.

Interventions

DRUGAripiprazole

single oral administration of aripiprazole

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

19 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers * right-handed

Exclusion criteria

* any significant abnormality on routine lab * any psychiatric disease

Design outcomes

Primary

Measure	Time frame
Reaction time of correct response in N-back task	48 hrs after the administration of aripiprazole

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026