Promotion of Breastfeeding Intervention Trial

Conditions

Effect of Breastfeeding on Maternal and Child Health Outcomes

Keywords

Breastfeeding, Child Health, Obesity, Blood Pressure, Asthma, Cognitive Development, Behavior, Eczema, Lung Function, Spirometry

Brief summary

The overall goal of the PROBIT study is to investigate the influence of a randomized breastfeeding promotion intervention designed to increase the duration and exclusivity of breastfeeding (the breastfeeding promotion intervention) on the development of maternal and child health outcomes. The hypothesis is that randomization to the intervention will be associated with lower child adiposity, lower risk of asthma and atopy, improved lung function, and improved cognitive outcomes.

Christopher G. Owen, Emily Oken, Alicja R. Rudnicka, Rita Patel, Jennifer Thompson et al. (11 authors)

Investigative Ophthalmology & Visual Science2018-06-017 citations

10.1167/iovs.17-23211

Breastfeeding during infancy and neurocognitive function in adolescence: 16-year follow-up of the PROBIT cluster-randomized trial

Seungmi Yang, Richard M. Martin, Emily Oken, Mikhail Hameza, Glen M. Doniger et al. (12 authors)

PLoS Medicine2018-04-2052 citations

10.1371/journal.pmed.1002554

Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years

Carsten Flohr, A. John Henderson, Michael S. Kramer, Rita Patel, Jennifer Thompson et al. (12 authors)

JAMA Pediatrics2017-11-1351 citations

10.1001/jamapediatrics.2017.4064

Effects of Promoting Long-term, Exclusive Breastfeeding on Adolescent Adiposity, Blood Pressure, and Growth Trajectories

Richard M. Martin, Michael S. Kramer, Rita Patel, Sheryl L. Rifas‐Shiman, Jennifer Thompson et al. (11 authors)

JAMA Pediatrics2017-05-0198 citations

10.1001/jamapediatrics.2017.0698

Prospective associations between problematic eating attitudes in midchildhood and the future onset of adolescent obesity and high blood pressure.

Wade KH, Kramer MS, Oken E, Timpson NJ, Skugarevsky O, Patel R, Bogdanovich N, Vilchuck K, Davey Smith G, Thompson J, Martin RM.

2016-12-1421 citations

10.3945/ajcn.116.141697

Socioeconomic differences in childhood length/height trajectories in a middle-income country: a cohort study.

Patel R, Tilling K, Lawlor DA, Howe LD, Bogdanovich N, Matush L, Nicoli E, Kramer MS, Martin RM.

2014-09-0817 citations

10.1186/1471-2458-14-932

Effects of Promoting Longer-Term and Exclusive Breastfeeding on Cardiometabolic Risk Factors at Age 11.5 Years

Richard M. Martin, Rita Patel, Michael S. Kramer, Konstantin Vilchuck, Natalia Bogdanovich et al. (13 authors)

Circulation2013-12-0472 citations

10.1161/circulationaha.113.005160

Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial.

Oken E, Patel R, Guthrie LB, Vilchuck K, Bogdanovich N, Sergeichick N, Palmer TM, Kramer MS, Martin RM.

2013-08-1439 citations

10.3945/ajcn.113.065300

Cohort profile: The promotion of breastfeeding intervention trial (PROBIT).

Patel R, Oken E, Bogdanovich N, Matush L, Sevkovskaya Z, Chalmers B, Hodnett ED, Vilchuck K, Kramer MS, Martin RM.

2013-03-0738 citations

10.1093/ije/dyt003

Effects of promoting longer-term and exclusive breastfeeding on adiposity and insulin-like growth factor-I at age 11.5 years: a randomized trial.

Martin RM, Patel R, Kramer MS, Guthrie L, Vilchuck K, Bogdanovich N, Sergeichick N, Gusina N, Foo Y, Palmer T, Rifas-Shiman SL, Gillman MW, Smith GD, Oken E.

2013-03-01126 citations

10.1001/jama.2013.167

Interventions

BEHAVIORALBreastfeeding promotion and support

Breastfeeding promotion and support according to the World Health Organization's Baby Friendly Hospital Initiative

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 3 Days

Healthy volunteers

No

Inclusion criteria

* Birth at one of 34 Maternity Hospitals in Republic of Belarus * Breastfeeding initiated at birth, with no contraindications to breastfeeding * Apgar score \>=5 at 5 minutes * Full term gestation * Birth weight \> 2500g

Design outcomes

Primary

Measure	Time frame	Description
Gastrointestinal tract infection	12 months of age	Occurrence of 1 or more episodes of gastrointestinal tract infection

Secondary

Measure	Time frame	Description
Child adiposity	Throughout childhood	—
asthma	6.5 and 16 years	—
cognition	6.5 and 16 years	—
dental caries	6.5 years	—
child behavior	6.5 years	—
vision	16 years	—
lung function	16 years	—
IGF-1	Age 11.5 years	IGF from dried bloodspots
child height	throughout childhood	Research measures of length/height
adiponectin	age 11.5 years	adiponectin from dried bloodspot
Apo A1	Child age 11.5 years	Apo A1 in dried bloodspots
Maternal adiposity	6.5 and 11.5 years postpartum	—
insulin	child age 11.5 years	insulin measured on dried blood spots
Apo B	Child age 11.5 years	Apo B measured in dried blood spots
Child blood pressure	throughout childhood	Research measures of blood pressure at ages 6.5, 11.5 and 16 years
Maternal blood pressure	11.5 years postpartum	Research measure of maternal blood pressure
Child metabolic syndrome	Age 11.5 years	—
Child growth	Throughout childhood	Growth in weight, length, weight for length, BMI, and other measures
Respiratory tract infections	to age 12 months and throughout childhood	Number of respiratory infections, from review of medical record
Atopic Eczema	Throughout childhood	Eczema from review of medical record, parent report,and direct examination
Atopy	Age 6.5 years	Skinprick tests for allergy
Eating Attitudes	Age 11.5 years	Children's Eating Attitudes Test (ChEAT) Questionnaire
glucose	child age 11.5 years	fingerstick glucose measured by glucometer

Countries

Belarus

Outcome results

None listed