Adverse Reaction to Epinephrine, Blood, Injection, Injury Type Phobia, Gastrointestinal Ulcer Haemorrhage
Conditions
Keywords
autologous blood, epinephrine, endoscopy, ulcer, hemostasis
Brief summary
Endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.
Detailed description
To test the hypothesis that endoscopic injection of autologous blood is superior to endoscopic injection of diluted epinephrine in controlling bleeding from gastroduodenal ulcers.
Interventions
DRUGEpinephrine
10-30 cc of 1/10000 diluted epinephrine will be injected at edges of an actively bleeding ulcer.
BIOLOGICALBlood
5-20 cc autologous blood immediately withdrawn from the patient will be injected at edges of the actively bleeding ulcer.
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* all adult patients with gastroduodenal ulcer
Exclusion criteria
* Patients with non ulcer bleeding. * Patients with malignancy. * Patients with bleeding disorders or under coagulation therapy. * Patients with known allergy to epinephrine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemostasis from the ulcer after injection and/or stoppage of haematemesis and melena one day after the procedure. | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| development of re-bleeding after 24 hours after the procedure (occurrence of hematemesis or melena or drop of hemoglobin level >2gm/dl). | 12 months |
Countries
Egypt
Outcome results
None listed