A New Non-invasive Marker to Detect Silent Hypoxia in Patients Undergoing Cardiac Surgery

The Somatic-to-cerebral Oxygen Saturation Gradient as a Non-invasive Index of Anaerobic Threshold in High-risk Cardiac Surgical Patient

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01560611

Enrollment

Registered

2012-03-22

Start date

2012-03-31

Completion date

Unknown

Last updated

2012-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaerobic Threshold, Cardiac Surgical Procedures, High-risk Surgical Patient

Brief summary

In patients undergoing cardiac surgery under cardiopulmonary bypass, some organs like brain and heart are preserved while others (skin, gut and skeletal muscle) are being underperfused. This phenomenon is related to silent peripheral vasoconstriction that is not clinically available but threatens end-organ perfusion and carries the risk of multi-organ failure. By measuring non-invasively the somatic-to-cerebral oxygen saturation gradient, the present study aims at detecting silent peroperative hypoperfusion episodes. The investigators hypothesize that gradient, measured during the surgical procedure, will predict the occurrence of anaerobic metabolism, ascertained by an elevation of blood lactate concentration, measured in intensive care unit.

Interventions

DEVICENear infrared spectroscopy

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 yo * Cardiac surgical procedure under cardiopulmonary bypass * High-risk surgical patient fulfilling one of the following items: * Euroscore \>= 6 * Ejection fraction \< 40% * Creatinine clearance \< 40mL/min * Pulmonary arterial pressure \> 45mmHg * Signed informed consent * Social security affiliation

Exclusion criteria

* Emergency situation * Patient on ECMO * Pregnancy or lactation

Countries

France

Contacts

Primary ContactJulien POTTECHER, MD

julien.pottecher@chru-strasbourg.fr33.3.88.12.70.95

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026