Opiate Dependent, Previous Illicit Drug Use
Conditions
Keywords
Analgesics, opioids, Opiate substitution treatment, Methadone, Buprenorphine, Hyperalgesia, Pupil, Pain, Psychophysics, previous illicit drug intake, under a substitution program
Brief summary
The purpose is to study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone/buprenorphine in opiate-dependent patients following a substitution program.
Detailed description
Patients substituted since at least 3 months shall be included during a regular control visit. Each session shall consist in * check for toxics in urine sample; * measurement of pupil diameter; * measurement of mechanical punctuate pain threshold; * measurement of mechanical bone pain threshold. A first session shall be done at time of residual effect of the opiate. A second session shall be done at time of peak effect of the opiate.
Interventions
DRUGBuprenorphine and Methadone Hydrochloride
To study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone / buprenorphine in opiate-dependent patients following a substitution program.
Sponsors
CSAPA ANPAA 63
University Hospital, Clermont-Ferrand
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* substitution treatment stable since at least 3 months * capacity to understand the protocol * likely to come to visits * covered by French welfare
Exclusion criteria
* chronic pain * concomitant acute pain * pregnancy or breast feeding * relevant mental disease * peripheral neuropathy * diabetes * regular intake of ketamine * neuroleptic concomitant treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the pupil diameter | 24 hours after the last dose of treatment |
Secondary
| Measure | Time frame |
|---|---|
| - The mechanical punctuate pain threshold as measured by Electronical Von Frey | 24 hours after the last dose of treatment, 3 hours after the last dose of methadone and 1 hour ½ after the last dose of buprenorphine |
| - The mechanical pressure pain threshold measured by Algometer on the tibial bone | 24 hours after the last dose of treatment, 3 hours after the last dose of methadone and 1 hour ½ after the last dose of buprenorphine |
| - The pupil diameter measured in scotopic .conditions (via infrared camera) at the hypothetical peak effect of either methadone or buprenorphine. | 24 hours after the last dose of treatment, 3 hours after the last dose of methadone and 1 hour ½ after the last dose of buprenorphine |
| - The pupil diameter measured in photopic conditions (via infrared camera) at the hypothetical residual effect of either methadone or buprenorphine | 24 hours after the last dose of treatment, 3 hours after the last dose of methadone and 1 hour ½ after the last dose of buprenorphine |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed