Oligoasthenospermia, Sperm Quality
Conditions
Brief summary
Myo-Inositol (MI) is a precursors for the synthesis of phosphatidylinositol polyphosphates (PIPs). In male reproduction, it was shown that MI concentration in the seminiferous tubules is higher than in serum and it was increasing during the movement through the epididymis and the deferent duct. In the present study, the role of myo-inositol has been investigated as a possible antioxidant agent for the systemic treatment of male infertility and the improvement of the sperm's quality. Samples of seminal fluid were obtained from two groups of patients undergoing to a IVF cycle: healthy subjects and subjects with oligoasthenospermia (OA, \< 15 mil/ml). The collected samples were submitted to optic microscopy in order to evaluate semen's volume, spermatozoa's number and motility, during the initial semen analysis and after density gradient separation method; these parameters were evaluated before and after the administration of 4000mg/die of myo-inositol associated to 400 µg of folic acid for three months. These values were compared with samples of seminal fluid of healthy patients undergoing to a IVF cycle for a female cause of infertility (control group).
Interventions
DIETARY_SUPPLEMENTmyo-inositol + folic acid
4000mg myo-inositol + 400 µg folic acid
Sponsors
AGUNCO Obstetrics and Gynecology Centre
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Inclusion criteria
* 3-5 days of sexual abstinence
Exclusion criteria
* systemic and endocrine diseases * genital infections * history of cryptorchidism or varicocele * microorchidism * hormonal treatment in the last six months * alcohol intake, cigarette smoke and/or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Semen volume | — |
| Spermatozoa count | — |
| Spermatozoa progressive motility | — |
| Number of spermatozoa after density gradient separation method | — |
Countries
Italy
Outcome results
None listed