Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication

Intraoperative Use of Dexketoprofen Trometamol, Tramadol Hcl, Pethidine Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01558622

Enrollment

Registered

2012-03-20

Start date

2012-03-31

Completion date

Unknown

Last updated

2012-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Nissen Fundoplication

Keywords

postoperative analgesia, dexketoprofen trometamol, tramadol hydrochloride, pethidine, laparoscopic Nissen fundoplication

Brief summary

The purpose of this study is to evaluate the analgesic effects of dexketoprofen trometamol, tramadol hydrochloride, pethidine hydrochloride and their combinations in laparoscopic Nissen fundoplication.

Interventions

DRUGdexketoprofen trometamol

50mg intravenous infusion

DRUGtramadol hydrochloride

100mg intravenous infusion

DRUGpethidine hydrochloride

50mg intravenous infusion

DRUGdexketoprofen trometamol + tramadol hydrochloride

intravenous infusion of 50mg dexketoprofen trometamol + 100mg tramadol hydrochloride

DRUGdexketoprofen trometamol + pethidine hydrochloride

intravenous infusion of 50mg dexketoprofen trometamol + 50mg pethidine hydrochloride

DRUGvitamin c

500mg intravenous infusion

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* 18-60 years old ASA I-II patients * Clinical diagnosis of gastroesophageal reflux patients

Exclusion criteria

* Allergic reactions to NSAIDs or opioid analgesics * Body mass index exceeding 35 * Pregnancy

Design outcomes

Primary

Measure	Time frame
Allergic reactions to NSAIDs or opioid analgesics, body mass index exceeding 35	postoperative 2 hours

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026