Aging
Conditions
Keywords
Exercise, Blood Flow, Nitric Oxide, Aging, Antioxidant, Flavanol, Young (18-30 yrs), Aging (60 - 80 yrs)
Brief summary
It has well known that diets rich in fruits, vegetables and cocoa products are associated with positive health benefits and these positive effects have been shown to be due to compounds they contain called flavanols. Flavanols have been shown to exert their positive effects by indirectly increasing nitric oxide (NO) bioavailability. NO is a potent vasodilator that is believed to play a role in increasing blood flow to active muscle during exercise. This regulatory process is impaired with healthy aging. The underlying premise to this study is that if NO bioavailability can be increased following flavanol ingestion, will there be a restoration of blood flow during exercise in older individuals? Accordingly, the first part of this research project will compare the acute vascular effects of flavanol ingestion between a young and old group. The investigators have hypothesized that both groups will show an improvement in blood flow to active muscle during exercise, though the magnitude of the change will be greater in the older group. The second part of this project will look at the effects of 4 weeks of daily flavanol ingestion in the old group. The investigators hypothesize that subjects will demonstrate an improvement in blood flow to active muscle during exercise after the 4 week intervention and that the magnitude of the change will be greater than the acute effects. Findings from this proposal will provide evidence for the efficacy of flavanols to be used (as a simple and safe lifestyle intervention) to reverse or combat impaired blood flow regulation in older individuals.
Interventions
DIETARY_SUPPLEMENTHigh Flavanol Trial
The experimental trial (high flavanol content) will involve the consumption of a beverage containing about 1000mg of cocoa flavanols.
DIETARY_SUPPLEMENTLow Flavanol Trial
The placebo trial (low flavanol content) will involve the consumption of a beverage containing 75 mg of cocoa flavanols.
DIETARY_SUPPLEMENTHigh Flavanol Trial; long-term
The experimental trial (high flavanol content) will involve the daily consumption of a beverage containing about 1000mg of cocoa flavanols for 4 weeks. Subjects will be provided with 28 packets of the beverage to take home with them.
DIETARY_SUPPLEMENTLow Flavanol Trial; long-term effects
The placebo trial (low flavanol content) will involve the daily consumption of a beverage containing 75 mg of cocoa flavanols for 4 weeks. Subjects will be provided with 28 packets to take home with them.
Sponsors
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and Females between 18 - 30 years old * Males and Females between 60 - 80 years old
Exclusion criteria
* cardiovascular and/or microvascular disease * blood clotting disorder * pregnant lady * current smoker (or regularly smoked within last year) * a history of an adverse reaction to cold * taking medications known to effect the autonomic nervous system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in femoral blood flow during exercise following flavanol consumption | During knee extension exercise, change from baseline in blood flow 2 hours post flavanol ingestion | Blood flow regulation to active muscles during knee extension exercise can be assessed by using ultrasound to measure blood flow in the femoral artery. This will be done before and after stimulation of the sympathetic nervous system. A baseline value will be obtained and then the measurement will be performed again 2 hours after flavanol ingestion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in flow-mediated dilation (FMD) following flavanol consumption | Change from baseline in FMD 2 hours post flavanol ingestion | Flow-mediated dilation is commonly used as an index of nitric oxide bioavailability. Nitric oxide is believed to play a role in blood flow regulation during exercise. A baseline value will be obtained and then the measurement will be performed again 2 hours after flavanol ingestion. |
Countries
United States
Outcome results
None listed