Heart Failure, Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Conditions
Brief summary
The purpose of this study is to determine whether mechanical alternans (alternating strong and weak heart beats with a constant beat-to-beat interval), can be used to predict malignant ventricular arrhythmias, requiring defibrillation or appropriate ICD therapies, and to predict progression of heart failure and death.
Interventions
None listed
Sponsors
Johns Hopkins University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* structural heart disease * ischemic or non-ischemic cardiomyopathy
Exclusion criteria
* pregnancy * age \< 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sudden arrhythmic death | 5 years | appropriate ICD therapy due to fast ventricular tachycardia or ventricular fibrillation, or sudden cardiac death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cardiovascular mortality | 5 years | — |
| all-cause death | 5 years | — |
| appropriate ICD therapies | 5 years | either ICD shock or antitachycardia pacing due to ventricular arrhythmia |
| composite heart failure endpoint | 5 years | pump-failure death, or heart transplantation, or heart failure hospitalization, whichever came first |
Countries
United States
Outcome results
None listed