Changes of Endothelial Function Before and After DSA in Patients With Diabetes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01556984

Enrollment

200

Registered

2012-03-19

Start date

2012-10-31

Completion date

2013-10-31

Last updated

2015-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Keywords

diabetic foot, digital subtraction angiography, endothelial function, Patients with diabetes, Age 40 to 70 years old, Endothelial function are determined

Brief summary

Endothelial dysfunction is the early step of atherosclerosis. Therefore, the investigators hypothesize that digital subtraction angiography (DSA) can damage endothelial function. In this study, the investigators will select 200 diabetic patients who have a DSA for diabetic foot screening. Also, the investigators will select 100 healthy subjects as controls. The endothelial function will be determined by high resolution ultrasound before and after DSA. The investigators will observe the changes of endothelial function after DSA assay.

Interventions

OTHERDSA assay

All patients with diabetic foot perform a DSA assay. Before and after DSA, endothelial function will be measured.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with diabetic foot * Age 40 to 70 years old

Exclusion criteria

* Heart failure * Renal failure * Acute infection

Design outcomes

Primary

Measure	Time frame
The changes of endothelial function	10 months

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026