Analysis of Cutaneous and Hematologic Disorders by High-Throughput Nucleic Acid Sequencing

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01556828

Enrollment

Registered

2012-03-16

Start date

2011-06-30

Completion date

2014-06-30

Last updated

2016-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous Lymphoma, Cutaneous T-cell Lymphoma, Mycosis Fungoides, Other Skin Disorders

Brief summary

The goal of this study is to identify genetic changes associated with the initiation, progression, and treatment response of response of cutaneous and hematologic disorders using recently developed high-throughput sequencing technologies. The improved understanding of the genetic changes associated with cutaneous and hematologic disorders may lead to improved diagnostic, prognostic and therapeutic options for these disorders.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years of age or older * Patient meets the clinical and/or pathologic criteria for the cutaneous or hematologic disorder being examined. * Patient is willing to provide skin biopsies and five 10 mL tubes of peripheral blood.

Exclusion criteria

\- Less than 18 years of age

Design outcomes

Primary

Measure	Time frame	Description
Number of mutations	2 years	Identify mutations, changes in DNA copy number, structural rearrangements, or altered coding and non-coding RNA expression

Countries

United States

Outcome results