Akershus Cardiac Examination (ACE) 1950 Study

Conditions

Atrial Fibrillation, Cardiovascular Diseases, Cerebrovascular Disorders, Heart Failure, Mild Cognitive Impairment

Keywords

Cardiovascular epidemiology, Prospective, observational cohort study, Biomarkers, Cardio- and cerebrovascular imaging

Brief summary

Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Detailed description

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway. Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015. Current status: 10-year follow-up examinations of all participants are undertaken in 2023-2025, and sub-studies are ongoing.

Peter Selmer Rønningen, Magnar Gangås Solberg, Marte Meyer Walle‐Hansen, Magnus Nakrem Lyngbakken, Mona K. Beyer et al. (15 authors)

BMC Cardiovascular Disorders2026-09-05

10.1186/s12872-026-06574-2

Blood pressure at age 40 and key features of cerebral small vessel disease at age 70: data from the ACE 1950 Study.

Walle-Hansen MM, Hagberg G, Myrstad M, Berge T, Vigen T, Ihle-Hansen H, Thommessen B, Ariansen I, Lyngbakken MN, Røsjø H, Rønning OM, Beyer MK, Tveit A, Ihle-Hansen H.

2025-10-09

10.1186/s12872-025-05140-6

Associations Between Growth Differentiation Factor 15 and Anxiety and Depression in the General Population: The Akershus Cardiac Examination 1950 Study

Ragnhild Dypvik, Katrine Kveli Fjukstad, Stian Lydersen, Trygve Berge, Arnljot Tveit et al. (9 authors)

Biopsychosocial Science and Medicine2025-02-01

10.1097/psy.0000000000001365

Systolic blood pressure at age 40 and 30-year stroke risk in men and women

Marte Meyer Walle‐Hansen, Guri Hagberg, Marius Myrstad, Trygve Berge, Thea Vigen et al. (13 authors)

Open Heart2024-08-012 citations

10.1136/openhrt-2024-002805

Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle‐Aged Cohort From the General Population

Håkon Ihle‐Hansen, Thea Vigen, Trygve Berge, Marte Meyer Walle‐Hansen, Guri Hagberg et al. (12 authors)

Journal of the American Heart Association2023-08-2365 citations

10.1161/jaha.123.030739

Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid‐60s: Data From the ACE 1950 Study

Peter Selmer Rønningen, Trygve Berge, Magnar Gangås Solberg, Steve Enger, Mohammad Osman Pervez et al. (13 authors)

Journal of the American Heart Association2022-05-277 citations

10.1161/jaha.121.023738

Diagnostic Thresholds for Pre–Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: <i>Data From the ACE 1950 Study</i>

Peder L. Myhre, Magnus Nakrem Lyngbakken, Trygve Berge, Ragnhild Røysland, Erika Nerdrum Aagaard et al. (13 authors)

Journal of the American Heart Association2021-05-1731 citations

10.1161/jaha.120.020447

Prevalence of atrial fibrillation and cardiovascular risk factors in a 63–65 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study

Trygve Berge, Magnus Nakrem Lyngbakken, Håkon Ihle‐Hansen, Jon Brynildsen, Mohammad Osman Pervez et al. (14 authors)

BMJ Open2018-07-0143 citations

10.1136/bmjopen-2018-021704

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study

Håkon Ihle‐Hansen, Thea Vigen, Hege Ihle‐Hansen, Ole Morten Rønning, Trygve Berge et al. (12 authors)

Journal of the American Heart Association2018-05-0846 citations

10.1161/jaha.118.008562

Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation.

Horjen AW, Seljeflot I, Berge T, Smith P, Arnesen H, Tveit A.

2017-12-282 citations

10.1186/s12959-017-0153-1

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

62 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Resident in Akershus County (as per October 2011, prior to study invitation) * Born in the year of 1950 * Ability to consent to participation

Design outcomes

Primary

Measure	Time frame
Outcomes related to CVD and CV-associated conditions	Maximum 35 years

Secondary

Measure	Time frame
Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc.	Maximum 35 years
Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc.	Maximum 35 years
Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc.	Maximum 35 years

Other

Measure	Time frame
Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort	Within 35 years
Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort	Maximum 35 years

Countries

Norway

Outcome results