Degenerative Lesion of Articular Cartilage of Knee
Conditions
Keywords
osteochondral defect of the knee
Brief summary
The purpose of the study is to evaluate prospectively the outcome of treatment interventions of knee osteochondral lesions Outerbridge grade III and IV.
Detailed description
The main purpose of the study is to prospectively evaluate the outcome of treatment interventions with replacement, repair and regenerative approaches, of osteochondral articular lesions or defects, Outerbridge grade III and IV, in terms of symptomatic and functional recovery 12 months after surgery.
Interventions
PROCEDUREknee surgery
Reparative, replacement or regenerative techniques, with or without associated osteotomy.
Sponsors
Ettore Sansavini Health Science Foundation
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
patients referred to the participating centers for symptomatic treatment of degenerative lesions of the knee, which meet the following inclusion criteria: * symptomatic osteochondral lesions of grade III or IV (according to classification of Outerbridge; * Axial deviation with chondral damage, correct or not; * Consent to the processing of personal data, signed and dated by patient; * Patients of both sexes and aged between 30 and 60 years; * Patients willing to participate actively in the rehabilitation program and to attend post-operative follow-up visits.
Exclusion criteria
* Patients with synovitis; * BMI\> 30; * Allergy to collagen or calcium phosphate; * Patients with neoplastic disease; * Patients with metabolic disorders, thyroid diseases, immune system disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score | 12 months post procedure | Primary outcome measure will be the outcome of innovative treatments with repairing, regenerative and replacement techniques, with or without associated osteotomy, of knee osteochondral severe lesions(Outerbridge grade III and IV) in terms of symptoms improvement as assessed by means of the International Knee Documentation Committee (IKDC) subjective Knee Evaluation Score at 12 months postoperatively. |
Secondary
| Measure | Time frame |
|---|---|
| functional activity on the Lysholm Knee Scale | 12 months post surgery |
| Tissue regeneration at magnetic resonance (MRI) | 12 months post surgery |
| functional recovery at International Knee Documentation Committee(IKDC) knee Examination | 12 months |
| Physical performance at Tegner activity score | 12 months post surgery |
Countries
Italy
Outcome results
None listed