Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease

Observational Study of Comparison of Echocardiographic Markers of Right Ventricular Function and Electrocardiographic Signs of Chronic Cor Pulmonale in Elderly Patient With COPD

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01554774

Acronym

PVR-COPD

Enrollment

Registered

2012-03-15

Start date

2012-03-31

Completion date

2012-07-31

Last updated

2015-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease, Cor Pulmonale, Pulmonary Hypertension

Keywords

COPD, PVR

Brief summary

Many studies have evaluated the viability of measuring the pulmonary vascular resistance (PVR) by non-invasive methods in patients with pulmonary hypertension, pulmonary thromboembolism, ischemic cardiopathy and valvular disease. The investigators have not found other studies which evaluate the PVR in elderly patients with COPD. The hypothesis is that in patients with COPD, the severity of obstruction, expressed by GOLD class, is associated with an increase of PVR.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to 90 Years

Healthy volunteers

Inclusion criteria

* diagnosis of COPD stage II, III or IV according to the GOLD guidelines * signed the informed consent

Exclusion criteria

* ischemic cardiopathy * severe valvular disease * atrial fibrillation * left bundle branch block

Design outcomes

Primary

Measure	Time frame	Description
right ventricular function and GOLD stages	cross sectional	To compare right ventricular function, evaluated by a non-invasive method such as echocardiography, with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.

Secondary

Measure	Time frame	Description
Right ventricular function and FEV1.	cross sectional	Compare right ventricular function, evaluated by a non-invasive method such as echocardiography, tricuspid annulus plane systolic excursion (TAPSE),pulmonary artery systolic pressure (PAPs) and fractional area change (FAC), with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients.
ECG and echocardiography parameters of cor pulmonale	cross sectional	The correlation between right ventricular function and the electrocardiographic parameters of cor pulmonale.
Right ventricle function and 6M-WT.	cross sectional	Evaluate the correlation between the hemodynamic indices of right ventricle and the six minute walking test (6M-WT).

Countries

Italy

Outcome results