Acute Kidney Injury
Conditions
Brief summary
The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it
Detailed description
NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem
Interventions
DRUGvitamin E +Selenium
vitamin E 400 IU once 8 hrs before operation selenium 150 mic once 8 hrs before operation
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients who are candidate for brain surgery under controlled hypotension
Exclusion criteria
* Positive history of renal disease * Positive history of diabetes mellitus, CHF, HTN, Breast cancer, fever, leukocytosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| increased amount of urinary or serum NGAL after controlled hypotension | from 2 hours to 24 hours after controlled hypotension |
Countries
Iran
Contacts
Primary ContactMahmoodreza Torkaman, resident
Outcome results
None listed