Analgesia Tolerance, Opioid Tolerance, Pain
Conditions
Keywords
Dextromethorphan, Morphine, Fentanyl, Opioid, analgesia, Efficacy
Brief summary
Effect of N-methyl D-aspartate (NMDA) receptor antagonist Dextromethorphan on Opiods analgesia and tolerance in Pediatric Intensive Care Unit Patients
Interventions
DRUGPlacebo
The study medicines shall be administered via tube.
DRUGDextromethorphan
The study medicines shall be administered via tube.
Sponsors
King Abdullah International Medical Research Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
Inclusion: * Patients above 2 years, admitted in PICU * On Morphine or Fentanyl infusions for more than 48 hours
Exclusion criteria
* Patients under 2 years of age * Patients with anticipated PICU length of stay less than 3 days. * Patients shall be excluded if Morphine or Fentanyl infusions not continued for the minimum duration of 72 hours after enrollment * Patients develops hemodynamic instability * Patients with Hepatic failure * Withdrawal request by parent(s)/guardian/family
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of N-methyl D-aspartate (NMDA) receptor antagonist Dextromethorphan on Opiods analgesia and tolerance in Pediatric Intensive Care Unit Patients | Two years | Control of pain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of N-methyl D-aspartate (NMDA) receptor antagonist Dextromethorphan on Opiods analgesia and tolerance in Pediatric Intensive Care Unit Patients | two years | Duration of ventilation in both groups |
Countries
Saudi Arabia
Outcome results
None listed