Rhinosinusitis
Conditions
Keywords
rhinosinusitis, cefditoren pivoxil
Brief summary
Cefditoren pivoxil has been used in rhinosinusitis treatment. However, little is known about the efficacy of this drug at low and high doses.
Detailed description
The investigation was a randomized, investigator-blinded, and parallel study, conducted in patients (age 1-15 years) with acute rhinosinusitis. Two groups of patients were randomized received low (10 MKD) or high (20 MKD) of drug for 14 days. Changes in sinus symptoms scores, response rate and adverse effect were evaluated at days 7 and 14. Relapse rate was recorded at days 21 and 28. Recurrence of sinus symptoms at day 60 were assessed.
Interventions
comparison of different dosages of cefditoren pivoxil
Sponsors
Thammasat University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
1 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
* children age 1-15 years old diagnosed acute rhinosinusitis
Exclusion criteria
* poor compliance * other infections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sinus symptoms scores | 14 days | Change of sinus sympotms scores from baseline in 2 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| relapse rate | at day 28 | The relapse rate of sinus symptoms scores at day 28. |
Countries
Thailand
Outcome results
None listed