STEMI
Conditions
Brief summary
This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.
Interventions
Sponsors
University of Bristol
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18 years old * Cardiac symptoms of \> 20 mins chest pain or equivalent. * ECG criteria consistent with STEMI (STEMI) * Proceeding with percutaneous angioplasty * Assent/ consent to the study
Exclusion criteria
* Known allergy to adenosine or gadolinium * Chronic atrial fibrillation * Renal impairment with eGFR \<30 * Contraindication to angiography * Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner) * Cardiogenic shock * Patients with special communication needs or altered consciousness. * Patients who do not give assent/consent to the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular obstruction | DAy 2-4 | Microvascular obstruction as a percentage of the left ventricle at 2-4 days. |
Countries
United Kingdom
Outcome results
None listed