Mild Cognitive Impairment
Conditions
Keywords
Mild Cognitive Impairment, Alzheimer's Disease
Brief summary
This study was planned 1) to identify individuals with Mild Cognitive Impairment (MCI) who convert to Alzheimer's Disease (AD), and 2) to explore factors associated with the conversion.
Interventions
None listed
Sponsors
Fudan University
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Cognitive concern reflecting a change in cognition reported by the patient or informant or clinician 2. Mini-Mental State Examination (MMSE) scores between 18-30 (inclusive) 3. Clinical Dementia Rating (CDR) =0.5; Memory Box score must be at least 0.5 4. Objective memory loss\* as evidenced by Auditory Verbal Learning test (AVLT-HS) 5. Essentially preserved activities of daily living based on Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL) 6. Not-demented, as defined by 'All-cause Dementia (see 3.4. All-cause Dementia) 7. Willing to and able to undergo all test procedures including neuroimaging, and agree to longitudinal follow up 8. Written informed consent for the participation of this study including repeated neuropsychological tests and MRI scans
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to Conversion from MCI to Probable AD Dementia | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Time to Conversion from MCI to Possible AD Dementia or Probable AD Dementia | 3 years |
| Time to Conversion from MCI to All-cause Dementia | 3 years |
| Overall survival | 3 years |
| Changes in Neuropsychological examinations | baseline, annual and 3 years |
| Changes in MRI | baseline, annual and 3 years |
Countries
China
Outcome results
None listed