Skip to content

Energy Expenditure, Sleep and Macronutrients

Energy Expenditure and Sleep in Response to Protein/Carbohydrate and Fat Ratio

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01551238
Enrollment
40
Registered
2012-03-12
Start date
2012-03-31
Completion date
2013-12-31
Last updated
2013-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Weight, Nutrition Disorders, Obesity, Overnutrition, Overweight, Signs and Symptoms

Keywords

Energy expenditure, Sleep, Protein, Carbohydrate

Brief summary

The purpose of this study is to determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.

Detailed description

The prevalence of obesity has increased worldwide to epidemic proportions. For long-term treatment success permanent lifestyle changes are necessary with regard to approach to food, physical activity patterns and behavior to emotional stress. Moreover, an association has been shown between sleep disturbance and obesity. Weight loss strategies regarding food intake regulation mainly focused on changing patterns of fat and carbohydrate consumption during the last decades. The role of protein has largely been ignored. However, protein has been observed to increase satiety and energy expenditure to a greater extent than carbohydrate and fat and can therefore reduce energy intake. However, it still has to be confirmed if this effect is permanent or transient over a longer period of time. Moreover, dietary intakes may significantly affect sleep when macronutrient intakes are manipulated. Since sleep deprivation has been recognized as a risk factor for obesity, improving sleep by a change in macronutrient intake would be promising in the treatment of obesity.

Interventions

Differences in protein content (energy percent) of meals

Sponsors

Maastricht University Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy * age between 18-35 years * BMI 18-27 kg/m2 * non-smoking * weight stable (weight change \< 3 kg during the last 6 months) * no sleeping problems * not using a more than moderate amount of alcohol (\> 10 consumptions/wk) * not using medication or supplements except for oral contraceptives in women

Exclusion criteria

* not healthy * do not meet the criteria for BMI and age * smoking * not being weight stable * using medication or supplements except for oral contraceptives in women * sleeping problems * using a more than moderate alcohol consumption * pregnant or lactating * allergic for the used food items

Design outcomes

Primary

MeasureTime frame
energy expenditure48 hours
substrate oxidation48 hours
sleep48 hours

Secondary

MeasureTime frame
body composition48 hours
fat distribution48 hours

Countries

Netherlands

Contacts

Primary ContactHanne K. Gonnissen, Msc.
hkj.gonnissen@maastrichtuniversity.nl+31433884596
Backup ContactEveline A. Martens, Msc.
eap.martens@maastrichtuniversity.nl+31433884596

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 19, 2026