Hyperbilirubinemia
Conditions
Keywords
preterm infants < 32 weeks of gestation
Brief summary
The aim of the study was to evaluate the influence of a systematic extra intravenous fluid supplementation during phototherapy in comparison to a fluid supplementation due to short term demand in preterm infants.
Detailed description
60 preterm infants (GA ≤ 32 week) were assigned randomly to either receive a fluid supplementation due to short term demand (control group, n=30;) or a 20% extra fluid supplementation (study group, n=30) during intermediate phototherapy. Collected data: * cardiorespiratory parameters(heart rate, blood pressure, SaO2 and capillary refill time, breathing rate, temperature) and a pain score was completed at the first day of phototherapy * The maximum total serum bilirubin levels (TSB) within one week after onset of phototherapy
Interventions
OTHERextra fluid/iv fluid supplementation during phototherapy
The study group received an extra intravenous fluid intake of 20% of the total fluid demand per 24 hours of NaCl 0,9% during each two hour period of phototherapy (12h total per day). The extra fluid intake was interrupted during the 12 hours break of phototherapy.
OTHERNon extra fluid
Control placebo The control group received the previous fluid regime, as intravenous fluid was given constantly, without a specific guideline according to extra fluid intake.
Sponsors
University of Jena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Weeks to 1 Weeks
Healthy volunteers
No
Inclusion criteria
* Hyperbilirubinemia
Exclusion criteria
* Preterm infants \> 33 weeks of gestation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The maximum total serum bilirubin levels | within one week after onset of phototherapy | The maximum total serum bilirubin levels within on week after onset of phototherapy |
Countries
Germany
Outcome results
None listed